(R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate

Base Information

• Chemical Name: (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate
• CAS No.: 1361214-45-0
• Molecular Formula: C₃₆H₃₈FN₃O₆
• Molecular Weight: 627.713
• Mol file: 1361214-45-0.mol

Synonyms:(R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate

Chemical Property of (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate

There total 10 articles about (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H29FN2O3 (1361214-42-7) + 2-(4(S)-phenyloxazolidin-2-on-3-yl)acetyl chloride (99333-55-8) → (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate (1361214-45-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmc.2011.12.013

Reference yield:

D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide (512785-16-9) → (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate (1361214-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C / desiccating agent

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2011.12.013

Reference yield:

N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide (512785-11-4) → (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate (1361214-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 18 h

2: dichloromethane / 20 °C / desiccating agent

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With 5%-palladium/activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.12.013

upstream raw materials:

D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

C₂₅H₂₉FN₂O₃

2-(4(S)-phenyloxazolidin-2-on-3-yl)acetyl chloride

Downstream raw materials:

(R)-3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

(R)-4-([1,4'-bipiperidin]-1'-yl)-2-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-N-((R)-1-phenylethyl)butanamide