4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Base Information

• Chemical Name: 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS No.: 1443646-78-3
• Molecular Formula: C₂₀H₂₁IN₂O₂S
• Molecular Weight: 480.369

Synonyms:4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property of 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property:

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Technology Process of 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

There total 11 articles about 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-allyl-N-(3-(2-(dimethylamino)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide (1443647-05-9) → 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1443646-78-3)

Guidance literature:

With iodine; In 1,2-dichloro-ethane; at 70 ℃; for 4h;

DOI:10.1021/ol401303f

Reference yield: 85.0%

N-allyl-N-(3-(2-(dimethylamino)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide (1443647-05-9) → N-allyl-N-((3-iodo-1-methyl-1H-indol-2-yl)methyl)-4-methylbenzenesulfonamide (1443646-76-1) + 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1443646-78-3)

Guidance literature:

With iodine; In 1,2-dichloro-ethane; at 70 ℃; for 4h; Solvent; Temperature; Time;

DOI:10.1021/ol401303f

Reference yield: 81.0%

N-allyl-N-(3-(2-(benzyl(methyl)amino)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide (1443647-16-2) → 4-(iodomethyl)-9-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1443646-78-3)

Guidance literature:

With iodine; In 1,2-dichloro-ethane; at 70 ℃; for 6h;

DOI:10.1021/ol401303f

upstream raw materials:

4-methyl-N-prop-2-ynylbenzenesulfonamide

N-tosyl-N-allylpropargylamine

N-allyl-N-(3-(2-(dimethylamino)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide

N-allyl-N-(3-(2-(benzyl(methyl)amino)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide

Downstream raw materials:

4,9-dimethyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

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