7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

Base Information

Chemical Name:7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline
CAS No.:933678-05-8
Molecular Formula:C₂₄H₂₄ClNO
Molecular Weight:377.914
Hs Code.:

Synonyms:7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

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Chemical Property of 7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

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Technology Process of 7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

There total 2 articles about 7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 19672-63-0
1-(4-chlorophenyl)-3-(4-methylphenyl)prop-2-en-1-one

: 126-81-8
dimedone

: 933678-05-8
7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

Guidance literature:: With ammonium acetate; In neat (no solvent); at 80 ℃; for 3h;
DOI:10.1007/s11164-012-0968-0

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 99-91-2
para-chloroacetophenone

: 933678-05-8
7,7-dimethyl-5-oxo-2-(4-chlorophenyl)-4-(4-methylphenyl)-1,4,5,6,7,8-hexahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide

2: ammonium acetate; triethylamine / neat (no solvent) / 0.83 h / 80 °C

With ammonium acetate; triethylamine; sodium hydroxide; In neat (no solvent); 1: |Claisen-Schmidt Condensation;
DOI:10.1007/s11164-014-1773-8