(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

Base Information

Chemical Name:(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester
CAS No.:170872-82-9
Molecular Formula:C₃₆H₄₅F₅N₂O₆
Molecular Weight:696.755
Hs Code.:

(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

Synonyms:(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

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Chemical Property of (4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

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Technology Process of (4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

There total 12 articles about (4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Methyl-N-((3R,4S)-4-methyl-5-oxo-tetrahydro-furan-3-yl)-benzenesulfonamide

: 170872-82-9
(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: aq. Ba(OH)2

3: DIEA, DMAP

4: DMAP

5: conc. HCl / methanol

6: (COCl)2 / dimethylsulfoxide

7: 1.) BuLi, 3.) sodium naphthalene, 4.) (COCl)2

8: 1.) LiOH, 2.) sodium naphthalene, 4.) DCC

With hydrogenchloride; dmap; barium dihydroxide; lithium hydroxide; n-butyllithium; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium naphthalenide; In methanol; dimethyl sulfoxide;
DOI:10.1021/ja00140a025

Reference yield:

: (2S,3R)-4-Hydroxy-2-methyl-3-(toluene-4-sulfonylamino)-butyric acid

: 170872-82-9
(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

2: DIEA, DMAP

3: DMAP

4: conc. HCl / methanol

5: (COCl)2 / dimethylsulfoxide

6: 1.) BuLi, 3.) sodium naphthalene, 4.) (COCl)2

7: 1.) LiOH, 2.) sodium naphthalene, 4.) DCC

With hydrogenchloride; dmap; lithium hydroxide; n-butyllithium; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium naphthalenide; In methanol; dimethyl sulfoxide;
DOI:10.1021/ja00140a025

Reference yield:

: (2S,3R)-4-Hydroxy-2-methyl-3-(toluene-4-sulfonylamino)-butyric acid methyl ester

: 170872-82-9
(4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DIEA, DMAP

2: DMAP

3: conc. HCl / methanol

4: (COCl)2 / dimethylsulfoxide

5: 1.) BuLi, 3.) sodium naphthalene, 4.) (COCl)2

6: 1.) LiOH, 2.) sodium naphthalene, 4.) DCC

With hydrogenchloride; dmap; lithium hydroxide; n-butyllithium; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium naphthalenide; In methanol; dimethyl sulfoxide;
DOI:10.1021/ja00140a025