5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Base Information

Chemical Name:5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one
CAS No.:185802-63-5
Molecular Formula:C₂₁H₁₇N₃O₂
Molecular Weight:343.385
Hs Code.:

Synonyms:5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

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Technology Process of 5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

There total 3 articles about 5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 185802-60-2
5-[2-(4-Nitro-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

: 185802-63-5
5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: With hydrogen; nickel; In N,N-dimethyl-formamide; for 1h; under 760 Torr;
DOI:10.1248/cpb.46.53

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 185802-63-5
5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / Ambient temperature

2: N,N-dimethylaniline / tetrahydrofuran / 5 h / Heating

3: 93 percent / H₂ / Raney-Ni / dimethylformamide / 1 h / 760 Torr

With oxalyl dichloride; hydrogen; N,N-dimethyl-aniline; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.53

Reference yield:

: 50434-36-1
4-nitrophenylacetyl chloride

: 185802-63-5
5-[2-(4-Amino-phenyl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethylaniline / tetrahydrofuran / 5 h / Heating

2: 93 percent / H₂ / Raney-Ni / dimethylformamide / 1 h / 760 Torr

With hydrogen; N,N-dimethyl-aniline; nickel; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.53