[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

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Chemical Name:[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
CAS No.:869893-64-1
Molecular Formula:C₅₀H₇₆O₉Si
Molecular Weight:849.234
Hs Code.:

[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Synonyms:[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

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Chemical Property of [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

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Technology Process of [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

There total 8 articles about [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 209542-21-2
2,2-dimethyl-3,3-diphenyl-4,7,10,13,16-pentaoxa-3-silaoctadecan-18-oic acid

: 869893-63-0
22-acetoxy-5α-23,24-bisnorchol-3β-ol

: 869893-64-1
[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h;
DOI:10.1016/j.tet.2005.08.085

Reference yield:

: 1159-24-6
17-(Z)-ethylidene-3β-hydroxy-5α-androstane

: 869893-64-1
[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h

2: 98 percent / BF₃*Et₂O / CH₂Cl₂ / 0.17 h / 20 °C

3: hydrogen / palladium(II) oxide / ethanol; ethyl acetate / 14 h

4: 50 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

5: 82 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl salt / CH₂Cl₂ / 24 h

With pyridine; dmap; dipyridinium dichromate; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium(II) oxide; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2005.08.085

Reference yield:

: 607733-97-1
5α-23,24-bisnorchol-16-en-22-ol-3-one

: 869893-64-1
[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (3S,5S,8R,9S,10S,13S,14S,17R)-17-((S)-2-acetoxy-1-methyl-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium(II) oxide / ethanol; ethyl acetate / 14 h

2: 50 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3: 82 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl salt / CH₂Cl₂ / 24 h

With pyridine; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium(II) oxide; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2005.08.085