3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

Base Information

Chemical Name:3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile
CAS No.:128564-73-8
Molecular Formula:C₂₈H₃₇N₃O₂
Molecular Weight:447.621
Hs Code.:

3,4-dimethoxy-α-(1-methylethyl)-α-<3-<methyl<2-(1-methyl-1H-indol-5-yl)ethyl>amino>propyl>benzeneacetonitrile

Synonyms:3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

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Chemical Property of 3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

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Technology Process of 3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

There total 4 articles about 3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 128564-72-7
1-methyl-1H-indole-5-acetaldehyde

: 67775-97-7
2-(3,4-Dimethoxy-phenyl)-2-isopropyl-5-methylamino-pentanenitrile; hydrochloride

: 128564-73-8
3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

Guidance literature:: With sodium acetate; sodium cyanoborohydride; In methanol; Ambient temperature;
DOI:10.1016/0223-5234(90)90028-2

Reference yield:

: 10075-52-2
5-bromo-1-methyl-H-indole

: 128564-73-8
3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) copper(I) iodide / 1.) RT, 90 min, THF/ether/hexane, 2.) -40 deg C, 3 h,

2: 61 percent / Dess-Martin Periodinane / CH₂Cl₂ / 2.5 h

3: 74 percent / sodium acetate, sodium cyanoborohydride / methanol / Ambient temperature

With copper(l) iodide; n-butyllithium; sodium acetate; sodium cyanoborohydride; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1016/0223-5234(90)90028-2

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 128564-73-8
3,4-dimethoxy-α-(1-methylethyl)-α-<3-amino>propyl>benzeneacetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) -78 deg C, THF, 2.) -78 deg C to RT, overnight

2: 1.) n-butyllithium, 2.) copper(I) iodide / 1.) RT, 90 min, THF/ether/hexane, 2.) -40 deg C, 3 h,

3: 61 percent / Dess-Martin Periodinane / CH₂Cl₂ / 2.5 h

4: 74 percent / sodium acetate, sodium cyanoborohydride / methanol / Ambient temperature

With copper(l) iodide; n-butyllithium; sodium acetate; sodium cyanoborohydride; Dess-Martin periodane; lithium hexamethyldisilazane; In methanol; dichloromethane;
DOI:10.1016/0223-5234(90)90028-2