methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate

Base Information

• Chemical Name: methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate
• CAS No.: 147404-00-0
• Molecular Formula: C₂₆H₂₆N₄O₃
• Molecular Weight: 442.517

Synonyms:methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate

Chemical Property of methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate

Chemical Property:

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Technology Process of methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate

There total 1 articles about methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-(2'-Cyano-biphenyl-4-ylmethyl)-2-propyl-3H-benzoimidazole-4-carboxylic acid methyl ester (136285-43-3) → 3-[2'-(N-Hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-2-propyl-3H-benzoimidazole-4-carboxylic acid methyl ester (147404-00-0)

Guidance literature:

With hydroxylamine; In dimethyl sulfoxide; at 75 ℃; for 15h;

DOI:10.1021/jm960547h

Reference yield: 86.0%

acetic anhydride (108-24-7) + 3-[2'-(N-Hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-2-propyl-3H-benzoimidazole-4-carboxylic acid methyl ester (147404-00-0) → C28H28N4O4 (147404-84-0)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm960547h

Reference yield:

methyl 1-[(2'-N-hydroxyamidino-biphenyl-4-yl)methyl]-2-propylbenzimidazole-7carboxylate (147404-00-0) + 2-Ethylhexyl chloroformate (24468-13-1) → methyl 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-2-propylbenzimidazol-7-carboxylate (147404-01-1)

Guidance literature:

With pyridine; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3-(2'-Cyano-biphenyl-4-ylmethyl)-2-propyl-3H-benzoimidazole-4-carboxylic acid methyl ester

Downstream raw materials:

C₂₈H₂₈N₄O₄

2-Propyl-3-[2'-(5-thioxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

methyl 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-2-propylbenzimidazol-7-carboxylate

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