(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Base Information

Chemical Name:(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine
CAS No.:1266784-94-4
Molecular Formula:C₃₂H₃₃N₃O₃
Molecular Weight:507.632
Hs Code.:

Synonyms:(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

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Chemical Property of (RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Chemical Property:

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Technology Process of (RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

There total 7 articles about (RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1013-88-3
Benzophenone imine

: 1266784-96-6
(RS)-[bis-(4-methoxy-phenyl)-phenyl-methyl]-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-amine

: 1266784-94-4
(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Guidance literature:: Benzophenone imine; (RS)-[bis-(4-methoxy-phenyl)-phenyl-methyl]-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-amine; With tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 105 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃;

With sodium hydroxide; In water; pH=14;

Reference yield:

: 1183013-69-5
(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

: 1266784-94-4
(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile / -2 - 20 °C

2.1: potassium tert-butylate / tert-Amyl alcohol / 20 - 30 °C

3.1: dichloromethane / 20 °C / Inert atmosphere

3.2: 16 h / 100 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 48 h / 105 °C / Inert atmosphere

5.2: 20 °C

5.3: pH 14

With potassium tert-butylate; triethylamine; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tert-Amyl alcohol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1183581-39-6
(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester

: 1266784-94-4
(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -5 - 5 °C

1.2: -7 - 20 °C

2.1: triethylamine / acetonitrile / -2 - 20 °C

3.1: potassium tert-butylate / tert-Amyl alcohol / 20 - 30 °C

4.1: dichloromethane / 20 °C / Inert atmosphere

4.2: 16 h / 100 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 48 h / 105 °C / Inert atmosphere

6.2: 20 °C

6.3: pH 14

With lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; tert-Amyl alcohol; dichloromethane; toluene; acetonitrile;