(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

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Chemical Name:(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone
CAS No.:1027259-59-1
Molecular Formula:C₃₇H₅₄N₂O₇S₂Si
Molecular Weight:731.062
Hs Code.:

(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

Synonyms:(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

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Chemical Property of (5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

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Technology Process of (5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

There total 10 articles about (5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1027259-59-1
(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

3: N,N-diisoropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

4: N,N-diisoropylethylamine / CH₂Cl₂ / 1 h / -78 °C

With triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.06.141

Reference yield:

: 76074-18-5
trimethyl-(2-nitro-phenyl)-stannane

: 1027259-59-1
(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide / 48 h / 20 °C

2: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

3: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

4: N,N-diisoropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

5: N,N-diisoropylethylamine / CH₂Cl₂ / 1 h / -78 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenyl-arsane; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1016/j.tet.2004.06.141

Reference yield:

: 482351-10-0
(3R)-3-[(1E)-3-[(4-methoxyphenyl)methoxy]-1-[[[tris-(1-methylethyl)silyl]oxy]methyl]-1-propenyl]cyclohexanone

: 1027259-59-1
(5R,6R)-5-[(E)-1-[(2,2-Bis-ethylsulfanyl-ethylamino)-methyl]-3-(4-methoxy-benzyloxy)-propenyl]-2-(2-nitro-phenyl)-6-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / I₂; DMAP / CH₂Cl₂ / 5 h / 20 °C

2: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide / 48 h / 20 °C

3: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

4: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

5: N,N-diisoropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

6: N,N-diisoropylethylamine / CH₂Cl₂ / 1 h / -78 °C

With dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenyl-arsane; iodine; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Stille coupling;
DOI:10.1016/j.tet.2004.06.141