(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1407543-86-5
Molecular Formula:C₂₈H₃₀N₆O₄
Molecular Weight:514.584
Hs Code.:

Synonyms:(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1407543-94-5
(S)-benzyl 2-((3'-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

: 1407543-86-5
(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 8h;
DOI:10.1055/s-0032-1316582

Reference yield:

: 1407543-93-4
(S)-benzyl 2-((3'-amino-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

: 1407543-86-5
(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-0032-1316582

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1407543-86-5
(S)-benzyl 2-((3'-((S)-pyrrolidine-2-carboxamido)-[2,2'-bipyridin]-3-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: copper / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / 20 °C / 760.05 Torr

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; copper; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1316582