diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

Base Information

Chemical Name:diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate
CAS No.:148120-72-3
Molecular Formula:C₂₇H₄₁O₅PSi
Molecular Weight:504.679
Hs Code.:

Synonyms:diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

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Chemical Property of diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

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Technology Process of diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

There total 5 articles about diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 140896-57-7
diisopropyl <(E)-3-(acetoxymethyl)-4-<(tert-butyldiphenylsilyl)oxy>but-1-enyl>phosphonate

: 148120-72-3
diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

Guidance literature:: With methanol; potassium carbonate; for 5h; Ambient temperature;
DOI:10.1021/jm00062a006

Reference yield:

: 1660-95-3
Tetraisopropyl methylenediphosphonate

: 148120-72-3
diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) n-hexane, n-heptane, RT, 15 min, 2.) n-hexane, n-heptane, RT, 15 min

2: 63 percent / HCl / methanol / 1.5 h / Ambient temperature

3: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 2 h / Ambient temperature

4: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature

5: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; methanol; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm00062a006

Reference yield:

: 140896-55-5
diisopropyl <(E)-4-hydroxy-3-(hydroxymethyl)but-1enyl>phosphonate

: 148120-72-3
diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 2 h / Ambient temperature

2: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature

3: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature

With 1H-imidazole; methanol; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; water;
DOI:10.1021/jm00062a006