((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

Base Information

Chemical Name:((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone
CAS No.:1427520-29-3
Molecular Formula:C₃₃H₄₁NO₄SSi
Molecular Weight:575.844
Hs Code.:

Synonyms:((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

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Chemical Property of ((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

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Technology Process of ((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

There total 3 articles about ((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1427519-98-9
(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-5-((tertbutyldimethylsilyl)oxy)-1,3-diphenylpent-1-yn-3-yl cyclopropanecarboxylate

: 1427520-29-3
((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

: 1759-53-1
cyclopropanecarboxylic acid

Guidance literature:: With Echavarren's catalyst; water; In 1,2-dichloro-ethane; at 80 ℃; for 24h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo400121j

Reference yield:

: 1383950-54-6
N-((2S,3S)-1-((tert-butyldimethylsilyl)oxy)-3-hydroxy-3,5-diphenylpent-4-yn-2-yl)-4-methylbenzenesulfonamide

: 1427520-29-3
((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: water; Echavarren's catalyst / 1,2-dichloro-ethane / 24 h / 80 °C / Inert atmosphere

With Echavarren's catalyst; water; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo400121j

Reference yield:

: C₃₄H₄₁NO₅SSi

: 1427520-29-3
((3R,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: water; Echavarren's catalyst / 1,2-dichloro-ethane / 24 h / 80 °C / Inert atmosphere

With Echavarren's catalyst; water; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo400121j