3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

Base Information

Chemical Name:3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium
CAS No.:535969-78-9
Molecular Formula:C₃₃H₃₂N₃O₃
Molecular Weight:518.635
Hs Code.:

Synonyms:3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

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Chemical Property of 3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

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Technology Process of 3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

There total 3 articles about 3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3546-21-2,89160-73-6
ethidium

: 535969-74-5
((R)-2-Phenyl-[1,3]dioxan-4-yl)-acetic acid

: 535969-78-9
3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0040-4039(03)00025-X

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 535969-78-9
3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / pTsOH / CH₂Cl₂ / 2 h / 40 °C

2: 64 percent / LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

3: 80 percent / HATU; HOAt / dimethylformamide / 12 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; toluene-4-sulfonic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00025-X

Reference yield:

: 163460-06-8
(3R)-3,5-dihydroxypentanoic acid methyl ester

: 535969-78-9
3-Amino-5-ethyl-6-phenyl-8-[2-((R)-2-phenyl-[1,3]dioxan-4-yl)-acetylamino]-phenanthridinium

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / pTsOH / CH₂Cl₂ / 2 h / 40 °C

2: 64 percent / LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

3: 80 percent / HATU; HOAt / dimethylformamide / 12 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; toluene-4-sulfonic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00025-X