diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate
CAS No.:130296-58-1
Molecular Formula:C₃₁H₃₃FN₄O₈
Molecular Weight:608.623
Hs Code.:

diethyl N-<4-<N-<<2-(acetoxymethyl)-3,4-dihydro-4-oxo-6-quinazolinyl>methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Synonyms:diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

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Technology Process of diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

There total 6 articles about diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 112889-01-7
Acetic acid 6-bromomethyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

: 106585-57-3
diethyl N-(2-fluoro-4-(N-prop-2-ynylamino)benzoyl)-L-glutamate

: 130296-58-1
diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1021/jm00173a025

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 130296-58-1
diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 57 percent / Na₂Cr₂O₇, cocnd. H₂SO₄ / acetic acid / 1 h / 90 °C

2: SOCl₂ / toluene / 1.5 h / Heating

3: Et₃N / CH₂Cl₂ / 2 h / 25 °C

4: 95 percent / iron powder, HOAc / 2 h / 50 °C

5: 60 percent / K₂CO₃ / toluene; dimethylformamide / 3 h / 110 - 120 °C

6: 12 percent / 2,6-lutidine / dimethylformamide / 24 h / 80 °C

With 2,6-dimethylpyridine; thionyl chloride; sodium dichromate; sulfuric acid; iron; potassium carbonate; acetic acid; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 130296-58-1
diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / toluene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h / 25 °C

3: 95 percent / iron powder, HOAc / 2 h / 50 °C

4: 60 percent / K₂CO₃ / toluene; dimethylformamide / 3 h / 110 - 120 °C

5: 12 percent / 2,6-lutidine / dimethylformamide / 24 h / 80 °C

With 2,6-dimethylpyridine; thionyl chloride; iron; potassium carbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025