5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

Base Information

Chemical Name:5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide
CAS No.:849792-49-0
Molecular Formula:C₂₆H₂₀ClN₅O₅S₂
Molecular Weight:582.06
Hs Code.:

Synonyms:5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

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Chemical Property of 5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

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Technology Process of 5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

There total 2 articles about 5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849793-87-9
(5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester

: 849792-48-9
[3-(4-amino-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazolin-7-yl]-benzyl-carbamic acid tert-butyl ester

: 849792-49-0
5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

Guidance literature:: (5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester; [3-(4-amino-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazolin-7-yl]-benzyl-carbamic acid tert-butyl ester; In toluene; for 3h; Heating / reflux;

With trifluoroacetic acid; In water;

Reference yield:

: 849792-47-8
2-amino-4-(benzyl-tert-butoxycarbonyl-amino)-benzoic acid methyl ester

: 849792-49-0
5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; toluene / 24 h / 90 °C

1.2: 12 - 24 h

2.1: toluene / 3 h / Heating / reflux

In N,N-dimethyl-formamide; toluene;