8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Base Information

Chemical Name:8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine
CAS No.:244274-73-5
Molecular Formula:C₃₁H₄₉NO₂Si₂
Molecular Weight:523.907
Hs Code.:

8-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Synonyms:8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Suppliers and Price of 8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

There total 13 articles about 8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 244274-69-9
(3S,8S,8aS)-3-(tert-butyldiphenylsilyloxymethyl)-8-(tert-butyldimethylsilyloxy)indolizidin-5-one

: 244274-73-5
8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T

Reference yield:

: 138629-30-8,138871-56-4
(S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate

: 244274-73-5
8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Guidance literature:: Multi-step reaction with 8 steps

1: LiEt₃BH / tetrahydrofuran / 3 h / -78 °C

2: BF₃*OEt₂ / diethyl ether / 0.5 h / 20 °C

3: 78 percent / TBSOTf / CH₂Cl₂ / 1 h / -80 °C

4: 90 percent / H₂; AcONa / Pd/C / tetrahydrofuran / 24 h / 20 °C

5: 88 percent / thiophenol; TMSOTf / CH₂Cl₂ / 1 h / 0 °C

6: 69 percent / NaOMe / methanol / 1 h / 0 °C

7: 96 percent / imidazole / dimethylformamide / 36 h / 20 °C

8: 71 percent / BH₃*DMS / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; boron trifluoride diethyl etherate; t-butyldimethylsiyl triflate; hydrogen; sodium methylate; sodium acetate; lithium triethylborohydride; thiophenol; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Reduction / 2: Alkylation / 3: Mannich reaction / 4: Catalytic hydrogenation / 5: Decarboxylation / 6: Rearrangement / 7: Substitution / 8: Reduction;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T

Reference yield:

: 81658-25-5,344884-10-2
2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

: 244274-73-5
8-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-indolizine

Guidance literature:: Multi-step reaction with 9 steps

1: 83 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: LiEt₃BH / tetrahydrofuran / 3 h / -78 °C

3: BF₃*OEt₂ / diethyl ether / 0.5 h / 20 °C

4: 78 percent / TBSOTf / CH₂Cl₂ / 1 h / -80 °C

5: 90 percent / H₂; AcONa / Pd/C / tetrahydrofuran / 24 h / 20 °C

6: 88 percent / thiophenol; TMSOTf / CH₂Cl₂ / 1 h / 0 °C

7: 69 percent / NaOMe / methanol / 1 h / 0 °C

8: 96 percent / imidazole / dimethylformamide / 36 h / 20 °C

9: 71 percent / BH₃*DMS / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; boron trifluoride diethyl etherate; t-butyldimethylsiyl triflate; hydrogen; sodium methylate; sodium acetate; lithium triethylborohydride; thiophenol; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Reduction / 3: Alkylation / 4: Mannich reaction / 5: Catalytic hydrogenation / 6: Decarboxylation / 7: Rearrangement / 8: Substitution / 9: Reduction;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T