5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

Base Information

Chemical Name:5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione
CAS No.:132672-22-1
Molecular Formula:C₂₄H₂₀N₂O₅
Molecular Weight:416.433
Hs Code.:

Synonyms:5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

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Chemical Property of 5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

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Technology Process of 5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

There total 9 articles about 5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[1-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-meth-(Z)-ylidene]-oxazolidine-2,4-dione

: 132672-22-1
5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; under 2068.6 Torr; Ambient temperature;
DOI:10.1021/jm00109a003

Reference yield:

: 2-Bromo-1-(5-methyl-2-m-tolyl-oxazol-4-yl)-ethanone

: 132672-22-1
5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1: NaOCH₃ / ethanol / Heating

2: NaBH₄ / tetrahydrofuran; methanol / 1 h / Ambient temperature

3: CF₃COOH, triethylsilane / 1 h / 0 °C

4: dimethylformamide / 18 h / 150 °C

5: Ni-Al alloy, 70percent aq. HCOOH / 2 h / Heating

6: anhyd. sodium acetate / 1.5 h / 120 °C / 0.1 Torr

7: m-chloroperbenzoic acid / dimethylformamide / 2.5 h / Ambient temperature

8: H₂ / 10percent Pd/C / tetrahydrofuran / 2068.6 Torr / Ambient temperature

With triethylsilane; sodium tetrahydroborate; formic acid; aluminum nickel; hydrogen; sodium methylate; sodium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a003

Reference yield:

: 5-[1-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one

: 132672-22-1
5-[2-(5-Methyl-2-m-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / dimethylformamide / 2.5 h / Ambient temperature

2: H₂ / 10percent Pd/C / tetrahydrofuran / 2068.6 Torr / Ambient temperature

With hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a003