12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Base Information

• Chemical Name: 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one
• CAS No.: 85222-85-1
• Molecular Formula: C₂₃H₂₂N₂O₂
• Molecular Weight: 358.44

Synonyms:12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Chemical Property of 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Chemical Property:

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Technology Process of 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

There total 3 articles about 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-bromo-3-methoxy-2-butenoate (26536-93-6) → 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one (85222-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / zinc powder / acetonitrile / 1) cooling with an ice-salt bath -> room temperature, 5 h, 2) room temp., 2 days

With zinc; In acetonitrile;

DOI:10.1021/jo00158a010

Reference yield:

2,9-Dibenzyl-4,9-dihydro-3H-β-carbolin-2-ium; bromide (85222-68-0) → 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one (85222-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / zinc powder / acetonitrile / 1) cooling with an ice-salt bath -> room temperature, 5 h, 2) room temp., 2 days

With zinc; In acetonitrile;

DOI:10.1021/jo00158a010

Reference yield:

(E)-4-(2,9-Dibenzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-3-methoxy-but-2-enoic acid methyl ester (85222-84-0) → 12-Benzyl-2-methoxy-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one (85222-85-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00158a010

upstream raw materials:

(E)-4-(2,9-Dibenzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-3-methoxy-but-2-enoic acid methyl ester

methyl 4-bromo-3-methoxy-2-butenoate

2,9-Dibenzyl-4,9-dihydro-3H-β-carbolin-2-ium; bromide

Downstream raw materials:

Δ^15,16-1-Benzyl-16-(methoxycarbonyl)-17,21-dioxoyohimbane

12-Benzyl-1,3,4,6,7,12b-hexahydro-2,4-dioxo-2H-indolo<2,3-a>quinolizine

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