2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

Base Information

Chemical Name:2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol
CAS No.:1179338-13-6
Molecular Formula:C₁₇H₂₅FN₂O₂
Molecular Weight:308.396
Hs Code.:

Synonyms:2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

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Chemical Property of 2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

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Technology Process of 2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

There total 4 articles about 2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179338-35-2
3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzaldehyde

: 1179336-46-9
2,2,2-trifluoro-1-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone trifluoroacetate

: 1179338-13-6
2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

Guidance literature:: 3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzaldehyde; 2,2,2-trifluoro-1-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone trifluoroacetate; With acetic acid; In 1-methyl-pyrrolidin-2-one; for 0.25h; Cooling with ice;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2.5h;

Reference yield:

: 50919-06-7
2-(2-fluorophenyl)ethanol

: 1179338-13-6
2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h / 20 °C / Cooling with ice

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 2.58 h / -78 °C

2.2: 1.17 h / -78 - 20 °C

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.25 h / Cooling with ice

3.3: 2.5 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; 1H-imidazole; n-butyllithium; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 1179338-34-1
tert-butyl(2-fluorophenethoxy)dimethylsilane

: 1179338-13-6
2-(3-(1-oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-2-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 2.58 h / -78 °C

1.2: 1.17 h / -78 - 20 °C

2.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.25 h / Cooling with ice

2.3: 2.5 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;