7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid

Base Information

• Chemical Name: 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid
• CAS No.: 121099-62-5
• Molecular Formula: C₂₃H₂₉FO₄
• Molecular Weight: 388.479

Synonyms:7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid

Chemical Property of 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid

Chemical Property:

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Technology Process of 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid

There total 5 articles about 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid (121099-59-0) → 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid (121099-62-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00090a009

Reference yield:

2,3,5-trimethylphenol (697-82-5) → 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid (121099-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

2: 97 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

3: 70 percent / NaBH₄ / tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; titanium tetrachloride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00090a009

Reference yield:

7-(4-fluorophenyl)-7-hydroxyheptanoic acid (103187-28-6) → 7-(4-fluorophenyl)-7-<2-hydroxy-5-(hydroxymethyl)-3,4,6-trimethylphenyl>heptanoic acid (121099-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

2: 97 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

3: 70 percent / NaBH₄ / tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; titanium tetrachloride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00090a009

upstream raw materials:

7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

2,3,5-trimethylphenol

7-(4-fluorophenyl)-7-hydroxyheptanoic acid

7-(4-fluorophenyl)-7-(2-hydroxy-3,4,6-trimethylphenyl)heptanoic acid

Downstream raw materials:

7-(4-Fluoro-phenyl)-7-(2-hydroxy-5-methoxymethyl-3,4,6-trimethyl-phenyl)-heptanoic acid

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