5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

Base Information

Chemical Name:5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one
CAS No.:909848-16-4
Molecular Formula:C₁₉H₁₄ClF₃N₂O₃
Molecular Weight:410.78
Hs Code.:

Synonyms:5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

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Chemical Property of 5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

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Technology Process of 5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

There total 6 articles about 5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 54416-90-9
3-chloro-5-iodo-2,6-dimethylpyridin-4(1H)-one

: 909849-02-1
[6-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3-pyridinyl]boronic acid

: 909848-16-4
5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

Guidance literature:: With palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 909849-01-0
5-bromo-2-({4-[(trifluoromethyl)oxy]phenyl}oxy)pyridine

: 909848-16-4
5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 8 h / -78 - 20 °C

1.2: 1 h / pH 2

2.1: palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 140 °C / Microwave irradiation

With n-butyllithium; palladium diacetate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 88545-07-7,909849-00-9
3-chloro-2,6-dimethyl-4(1H)-pyridinone

: 909848-16-4
5-chloro-2,6-dimethyl-6'-({4-[(trifluoromethyl)oxy]phenyl}oxy)-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; iodine / water / 1 h / 20 °C

2: palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 140 °C / Microwave irradiation

With iodine; palladium diacetate; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256