5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Base Information

Chemical Name:5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS No.:1259536-62-3
Molecular Formula:C₁₈H₈Cl₂F₄N₄O
Molecular Weight:443.187
Hs Code.:

Synonyms:5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Suppliers and Price of 5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
QO58 ≥98%(HPLC)
50
$ 844.00

Tocris
QO58 ≥98%(HPLC)
10
$ 201.00

Total 3 raw suppliers

Chemical Property of 5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

QO58 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses QO 58 is a novel potassium channel opener, which modulates Kv7/M channel function.

Technology Process of 5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

There total 3 articles about 5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 62649-36-9
4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine

: 1259536-62-3
5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: With acetic acid; at 125 ℃; for 4h;
DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

: 1259536-96-3
C₁₀H₅F₃NO^(1-)*Na⁽¹⁺⁾

: 1259536-62-3
5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

2: acetic acid / 4 h / 125 °C

With acetic acid; hydrazinium sulfate; In carbonic acid dimethyl ester;
DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

: 140-29-4
phenylacetonitrile

: 1259536-62-3
5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; sodium / 2 h / 50 °C / Reflux

2: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

3: acetic acid / 4 h / 125 °C

With ethanol; sodium; acetic acid; hydrazinium sulfate; In carbonic acid dimethyl ester;
DOI:10.1016/j.ejmech.2011.01.010