(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate
CAS No.:1413399-67-3
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

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Chemical Property of (R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

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Technology Process of (R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

There total 9 articles about (R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413399-65-1
C₂₄H₃₁NO₅

: 1413399-67-3
(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

Guidance literature:: C₂₄H₃₁NO₅; With dmap; tert-butyldimethylsilyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

With pyridine; methanesulfonyl chloride; at 0 - 20 ℃; for 2h;

With tetrabutyl ammonium fluoride; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1021/jo4010553

Reference yield:

: 1413399-64-0
(R)-ethyl 2-((S)-(benzhydryloxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine-1-carboxylate

: 1413399-67-3
(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dowex 50 H⁺ / methanol / 12 h / Reflux

2.1: triethylamine; dmap; tert-butyldimethylsilyl chloride / dichloromethane / 12 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

2.3: 1.5 h / 20 °C

With dmap; tert-butyldimethylsilyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo4010553

Reference yield:

: 1413399-62-8
(R)-1-allyl-2-((S)-(benzhydryloxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine

: 1413399-67-3
(R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane / 12 h / 20 °C / Reflux

2.1: Dowex 50 H⁺ / methanol / 12 h / Reflux

3.1: triethylamine; dmap; tert-butyldimethylsilyl chloride / dichloromethane / 12 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

3.3: 1.5 h / 20 °C

With dmap; sodium hydrogencarbonate; tert-butyldimethylsilyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo4010553