(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

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Chemical Name:(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
CAS No.:1304773-34-9
Molecular Formula:C₃₂H₃₅FN₂O₈S
Molecular Weight:626.703
Hs Code.:

Synonyms:(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

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Chemical Property of (S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

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Technology Process of (S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

There total 5 articles about (S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1304773-47-4
1-(bromomethyl)-4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-benzene

: 220509-98-8
5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

: 1304773-34-9
(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

Guidance literature:: 5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

1-(bromomethyl)-4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-benzene; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.03.015

Reference yield:

: 106-44-5
p-cresol

: 1304773-34-9
(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 48 h / Reflux

2.1: acetonitrile / 24 h / Inert atmosphere; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 24 h / 20 - 80 °C / Inert atmosphere

4.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

5.2: 1 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium hydride; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.03.015

Reference yield:

: 416877-62-8
1-(2-(2-bromoethoxy)ethoxy)-4-methylbenzene

: 1304773-34-9
(S)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 24 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 24 h / 20 - 80 °C / Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.03.015