diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate

Base Information

• Chemical Name: diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate
• CAS No.: 952023-79-9
• Molecular Formula: C₂₁H₃₄O₆Si
• Molecular Weight: 410.583
• Mol file: 952023-79-9.mol

Synonyms:diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate

Chemical Property of diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate

There total 2 articles about diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

tert-butyldimethyl(pent-4-yn-2-yloxy)silane (885680-12-6) + diethyl 1,3-acetonedicarboxylate (105-50-0) → diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate (952023-79-9)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2007.07.020

Reference yield:

4-<(dimethyl-tert-butylsilyl)oxy>-1-pentyne (80186-44-3) → diethyl 4-(2-tert-butyldimethylsilyloxy)propyl-2-hydroxyisophthalate (952023-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 91 percent / tetrahydrofuran; hexane / 0.17 h

2.1: 54 percent / Cs₂CO₃ / tetrahydrofuran / 48 h / 20 °C

With n-butyllithium; caesium carbonate; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2007.07.020

upstream raw materials:

tert-butyldimethyl(pent-4-yn-2-yloxy)silane

diethyl 1,3-acetonedicarboxylate

4-<(dimethyl-tert-butylsilyl)oxy>-1-pentyne