2-Aminothiazole-4-carbaldehyde

Base Information

• Chemical Name: 2-Aminothiazole-4-carbaldehyde
• CAS No.: 98020-38-3
• Molecular Formula: C4H4 N2 O S
• Molecular Weight: 128.155
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID00376873
• Wikidata: Q82165777
• Mol file: 98020-38-3.mol

Synonyms:2-Aminothiazole-4-carbaldehyde;98020-38-3;2-Amino-4-formylthiazole;2-amino-1,3-thiazole-4-carbaldehyde;SCHEMBL1042072;DTXSID00376873;4-Thiazolecarboxaldehyde,2-amino-;MFCD07787389;AKOS006284448;AS-76762;CS-0054972;D97493;EN300-7312737

Chemical Property of 2-Aminothiazole-4-carbaldehyde

Chemical Property:

• Boiling Point: 316.3±15.0 °C(Predicted)
• PKA: 2.73±0.10(Predicted)
• PSA: 84.22000
• Density: 1.488±0.06 g/cm3(Predicted)
• LogP: 1.11900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 128.00443393
• Heavy Atom Count: 8
• Complexity: 98

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-AMINOTHIAZOLE-4-CARBALDEHYDE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(S1)N)C=O

Technology Process of 2-Aminothiazole-4-carbaldehyde

There total 1 articles about 2-Aminothiazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(4-formyl-thiazol-2-yl)-carbamic acid tert-butyl ester (494769-34-5) → 2-Amino-4-formyl-thiazol (98020-38-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 20h;

Reference yield: 56.0%

(2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid (300355-22-0) + 2-Amino-4-formyl-thiazol (98020-38-3) → C19H22N2O4S2 (1001419-63-1)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

upstream raw materials:

(4-formyl-thiazol-2-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

C₁₉H₂₂N₂O₄S₂

Refernces