2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

Base Information

Chemical Name:2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide
CAS No.:1201673-93-9
Molecular Formula:C₂₇H₃₂N₆O
Molecular Weight:456.591
Hs Code.:

Synonyms:2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

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Chemical Property of 2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

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Technology Process of 2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

There total 9 articles about 2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1201675-41-3
4-(4-carbamoyl-2'-cyclohexylamino-3-phenyl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1201673-93-9
2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

Guidance literature:: 4-(4-carbamoyl-2'-cyclohexylamino-3-phenyl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 1201674-86-3
4-(6-bromo-4-methoxycarbonylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1201673-93-9
2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 4 h / 80 °C

2.1: bromine; potassium acetate / dichloromethane / 0 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.75 h / 130 °C / Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.2: pH 6

5.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

6.1: copper (II)-fluoride / 12 h / 150 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h

With copper (II)-fluoride; water; bromine; potassium acetate; sodium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1201675-37-7
3-bromo-6-(4-tert-butoxycarbonyl-piperazin-1-yl)-2'-fluoro-[2,4']bipyridinyl-4-carboxylic acid methyl ester

: 1201673-93-9
2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.75 h / 130 °C / Microwave irradiation

2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 6

3.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4.1: copper (II)-fluoride / 12 h / 150 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h

With copper (II)-fluoride; water; sodium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;