(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Base Information

Chemical Name:(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide
CAS No.:925456-56-0
Molecular Formula:C₂₉H₂₈N₂O₅S
Molecular Weight:516.618
Hs Code.:

Synonyms:(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Chemical Property of (R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Technology Process of (R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

There total 5 articles about (R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 882424-05-7
(R)-(4-amino-3,4-dihydro-2H-chromen-7-yl)methanol

: 193634-01-4
(R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid

: 925456-56-0
(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 22 ℃; for 15h;
DOI:10.1021/jm070055c

Reference yield:

: 614-19-7,3646-50-2,13921-90-9,40856-44-8
(R)-3-phenyl-3-aminopropionic acid

: 925456-56-0
(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / sodium carbonate monohydrate / dioxane; H₂O / 15 h / 23 °C

2: 61 percent / 1-hydroxybenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 15 h / 22 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm070055c

Reference yield:

: 885104-10-9
(R)-methyl 4-azido-3,4-dihydro-2H-chromene-7-carboxylate

: 925456-56-0
(R)-N-((R)-7-(hydroxymethyl)-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / -15 - 20 °C

2: HOBt; silica-supported carbodiimide / tetrahydrofuran; dimethylformamide / 36 h / 20 - 35 °C

With lithium aluminium tetrahydride; silica-supported carbodiimide; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm061224g