N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

Base Information

Chemical Name:N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide
CAS No.:157065-36-6
Molecular Formula:C₂₅H₂₅F₆N₃O₃
Molecular Weight:529.482
Hs Code.:

Synonyms:N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

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Chemical Property of N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

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Technology Process of N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

There total 1 articles about N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 13139-14-5
Boc-Trp-OH

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 157065-36-6
N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

Guidance literature:: Boc-Trp-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

3,5-bis-trifluoromethylbenzylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/S0968-0896(02)00144-X

Reference yield: 95.0%

: 157065-36-6
N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

: L-tryptophan 3,5-bis(trifluoromethyl)benzylamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 16h;
DOI:10.1016/S0968-0896(02)00144-X

Reference yield:

: 157065-36-6
N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide

: 500725-28-0
{5-[1-(3,5-bis-trifluoromethyl-benzylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-pyrrolidin-2-ylidene}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / HCl / methanol / 16 h / 20 °C

2: 71 percent / PyBOP; DIPEA / CH₂Cl₂ / 48 h

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(02)00144-X