(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

Base Information

Chemical Name:(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one
CAS No.:934634-52-3
Molecular Formula:C₂₀H₁₆F₃N₃O₃
Molecular Weight:403.361
Hs Code.:

Synonyms:(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

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Chemical Property of (+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

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Technology Process of (+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

There total 5 articles about (+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 850038-83-4
3-hydroxy-7-trifluoromethyl-3H-isobenzofuran-1-one

: 143-33-9,25596-52-5
sodium cyanide

: 18807-71-1
benzyl N-(2-aminoethyl)carbamate hydrochloride

: 934634-52-3
(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

Guidance literature:: With sodium acetate; acetic acid; In ethanol;
DOI:10.1021/jm0612968

Reference yield:

: 433-97-6
2-trifluoromethylbenzoic acid

: 934634-52-3
(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride / DMF / CH₂Cl₂ / 2.5 h

2.1: 4.3 g / CH₂Cl₂ / 16 h

3.1: N,N,N',N'-tetramethylethylenediamine; sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 88 percent / tetrahydrofuran; hexane / 1 h

4.1: 99 percent / aq. HCl / 12 h / 100 °C

5.1: 66 percent / NaOAc; AcOH / ethanol

With hydrogenchloride; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium acetate; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/jm0612968

Reference yield:

: 850038-82-3
N,N-diethyl-2-carboxaldehyde-6-trifluoromethylbenzamide

: 934634-52-3
(+/-)-2-[2-[(benzyloxycarbonyl)amino]ethyl]-1-carbonitrile-1,3-dihydro-4-trifluoromethylisoindol-3(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / aq. HCl / 12 h / 100 °C

2: 66 percent / NaOAc; AcOH / ethanol

With hydrogenchloride; sodium acetate; acetic acid; In ethanol;
DOI:10.1021/jm0612968