1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246246-96-7
Molecular Formula:C₃₉H₅₃FN₆O₄
Molecular Weight:688.886
Hs Code.:

Synonyms:1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

There total 8 articles about 1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246246-97-8
C₄₄H₆₁FN₆O₆

: 1246246-96-7
1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 4h;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1246246-96-7
1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

3.2: 1 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; hydrogen; pivaloyl chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 123183-72-2
N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane

: 1246246-96-7
1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

3.2: 1 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; hydrogen; pivaloyl chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;