pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

Base Information

Chemical Name:pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide
CAS No.:106513-16-0
Molecular Formula:C₄₂H₆₄N₁₄O₁₅
Molecular Weight:1005.05
Hs Code.:

Synonyms:pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

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Chemical Property of pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

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Technology Process of pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

There total 11 articles about pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 111705-68-1
pyroglutamyl-alanyl-N^ε-benzyloxycarbonyllysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

: 106513-16-0
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

Guidance literature:: With hydrogen; palladium; In water; acetic acid; for 3h; Ambient temperature;

Reference yield:

: 51342-92-8
L-asparginyl-L-phenylalanyl methyl ester

: 106513-16-0
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1) pivaloyl chloride, N-ethylpiperidine, pyridine / 1) dichloromethane, 8 min., 0 deg C; 2) 2 h, room temp.

2: 78 percent / liq. NH₃ / methanol; H₂O / 70 h / Ambient temperature

3: 96 percent / H₂ / Pd-black / acetic acid; methanol; H₂O / 3 h / Ambient temperature

4: 1) NaNO₂, N-ethylpiperidine ; 2) N-ethylpiperidine / 1) conc. HCl, DMF, 10 min., -20 deg C; 2) 12 h, 0 deg C

5: 86 percent / H₂ / Pd-black / dimethylformamide; methanol; acetic acid / 6 h / Ambient temperature

6: 1) NaNO₂, N-ethylpiperidine, conc. HCl ; 2) N-ethylpiperidine / 1) DMF, 10 min., -20 deg C; 2) 12 h, 0 deg C

7: 64 percent / H₂ / Pd-black / acetic acid; H₂O / 3 h / Ambient temperature

With 1-ethyl-piperidine; pyridine; hydrogenchloride; ammonia; hydrogen; pivaloyl chloride; sodium nitrite; palladium; In methanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 106513-29-5
seryl-asparaginyl-phenylalanine amide

: 106513-16-0
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparaginyl-phenylalanine amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaNO₂, N-ethylpiperidine ; 2) N-ethylpiperidine / 1) conc. HCl, DMF, 10 min., -20 deg C; 2) 12 h, 0 deg C

2: 86 percent / H₂ / Pd-black / dimethylformamide; methanol; acetic acid / 6 h / Ambient temperature

3: 1) NaNO₂, N-ethylpiperidine, conc. HCl ; 2) N-ethylpiperidine / 1) DMF, 10 min., -20 deg C; 2) 12 h, 0 deg C

4: 64 percent / H₂ / Pd-black / acetic acid; H₂O / 3 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen; sodium nitrite; palladium; In methanol; water; acetic acid; N,N-dimethyl-formamide;