methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

Base Information

Chemical Name:methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate
CAS No.:103789-20-4
Molecular Formula:C₂₂H₂₂BrNO₅
Molecular Weight:460.324
Hs Code.:

Synonyms:methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

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Chemical Property of methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

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Technology Process of methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

There total 7 articles about methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[4-(2-Hydroxy-ethyl)-5-methyl-oxazol-2-yl]-phenol

: 103789-20-4
methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a012

Reference yield:

: 141399-34-0
4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-phenylamine

: 103789-20-4
methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a012

Reference yield:

: 103788-74-5
2-Cyclohexyl-4-[2-(4-nitro-phenoxy)-ethyl]-thiazole

: 103789-20-4
methyl 2-bromo-3-<4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy} phenyl>propionate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd/C / methanol / Ambient temperature

2: NaH / dimethylformamide / 1 h / Ambient temperature

3: H₂ / 10 percent Pd/C / methanol / Ambient temperature

4: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a012