6-Chloronicotinohydrazide

Base Information

• Chemical Name: 6-Chloronicotinohydrazide
• CAS No.: 168893-66-1
• Molecular Formula: C6H6ClN3O
• Molecular Weight: 171.586
• Hs Code.: 2933399990
• European Community (EC) Number: 832-109-1
• DSSTox Substance ID: DTXSID30384148
• Wikidata: Q72458451
• Mol file: 168893-66-1.mol

Synonyms:6-chloropyridine-3-carbohydrazide;168893-66-1;6-Chloronicotinohydrazide;2-Chloropyridine-5-carbohydrazide;6-Chloronicotinic acid hydrazide;3-Pyridinecarboxylic acid, 6-chloro-, hydrazide;SCHEMBL931481;DTXSID30384148;BIECNFYNFQQRRP-UHFFFAOYSA-N;AMY24831;MFCD00221429;AKOS005203387;PS-4677;A3732;CS-0216403;FT-0621091;EN300-42282;J-010489;J-518631;Z58981925

Chemical Property of 6-Chloronicotinohydrazide

Chemical Property:

• Melting Point: 250 °C
• Refractive Index: 1.599
• PSA: 68.01000
• Density: 1.405 g/cm³
• LogP: 1.42970
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 171.0199395
• Heavy Atom Count: 11
• Complexity: 153

Purity/Quality:

99% ^*data from raw suppliers

6-Chloronicotinohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1C(=O)NN)Cl

Technology Process of 6-Chloronicotinohydrazide

There total 1 articles about 6-Chloronicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

→ 6-chloropyridine-3-carboxylic acid hydrazide (168893-66-1)

Guidance literature:

With thionyl chloride; In methanol; at 50 ℃; for 4h; Cooling with ice;

With hydrazine hydrate; In ethanol; for 4h; Reflux;

Reference yield: 25.0%

6-chloropyridine-3-carboxylic acid hydrazide (168893-66-1) + 3-fluoro-4-(α-D-mannopyranosyloxy)benzaldehyde → (E)-6-chloro-N'-[3-fluoro-4-(α-D-mannopyranosyloxy)benzylidene]nicotinohydrazide

Guidance literature:

With acetic acid; In water; acetonitrile; at 20 ℃; Reagent/catalyst;

DOI:10.24820/ark.5550190.p010.913

Refernces