4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

Base Information

Chemical Name:4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid
CAS No.:1200575-96-7
Molecular Formula:C₂₃H₂₅NO₆
Molecular Weight:411.455
Hs Code.:

Synonyms:4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

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Chemical Property of 4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

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Technology Process of 4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

There total 6 articles about 4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1200575-95-6
ethyl 4-{6-[4-(methoxycarbonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 1200575-96-7
4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

Guidance literature:: ethyl 4-{6-[4-(methoxycarbonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate; With water; potassium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 1h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 1200575-51-4
benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate

: 1200575-96-7
4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 60 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

4.2: pH 2

With water; hydrogen; potassium carbonate; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1200575-96-7
4-{2-[1-(ethoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

3.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 60 °C

4.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

5.2: pH 2

With water; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;