(Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene

Base Information

• Chemical Name: (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene
• CAS No.: 718615-59-9
• Molecular Formula: C₁₃H₁₆ClFO₂S
• Molecular Weight: 290.786
• Mol file: 718615-59-9.mol

Synonyms:(Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene

Chemical Property of (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene

There total 3 articles about (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

6-chloro-2-hexanone (10226-30-9) + phosphonic acid diethyl ester (135789-87-6,114968-97-7) → (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene (718615-59-9) + (E)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene

Guidance literature:

phosphonic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

6-chloro-2-hexanone; In tetrahydrofuran; at -78 - -40 ℃; for 2h;

Reference yield:

diethyl phenylsulfonylmethylphosphonate (56069-39-7) → (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene (718615-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Selectfluor

2.1: LHMDS / tetrahydrofuran / 0.33 h / -78 °C

2.2: 35 percent / tetrahydrofuran / 2 h / -78 - -40 °C

With Selectfluor; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

diethyl [(phenylthio)methyl]phosphonate (38066-16-9) → (Z)-6-chloro-1-fluoro-2-methyl-1-(phenylsulfonyl)-1-hexene (718615-59-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Oxone

2.1: Selectfluor

3.1: LHMDS / tetrahydrofuran / 0.33 h / -78 °C

3.2: 35 percent / tetrahydrofuran / 2 h / -78 - -40 °C

With Oxone; Selectfluor; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

6-chloro-2-hexanone

phosphonic acid diethyl ester

diethyl [(phenylthio)methyl]phosphonate

diethyl phenylsulfonylmethylphosphonate