N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Base Information

• Chemical Name: N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide
• CAS No.: 1414850-50-2
• Molecular Formula: C₂₂H₁₈FNO₂S
• Molecular Weight: 379.455
• Mol file: 1414850-50-2.mol

Synonyms:N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property of N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

There total 4 articles about N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1,2-dibromovinyl)benzene (6607-46-1) + N-[(4-fluorophenyl)methyl]-4-methylbenzenesulfonamide (570417-42-4) → N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1414850-50-2)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In tetrahydrofuran; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2012.09.092

Reference yield: 80.0%

N-[(4-fluorophenyl)methyl]-4-methylbenzenesulfonamide (570417-42-4) + 1-Bromo-2-phenylacetylene (932-87-6) → N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1414850-50-2)

Guidance literature:

With 1,10-Phenanthroline; potassium carbonate; copper(II) sulfate; In toluene; at 80 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jacs.0c10682

Reference yield:

phenylacetylene (536-74-3) → N-(4-fluorobenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1414850-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 3 h / 20 °C

2: potassium carbonate; copper(II) sulfate heptahydrate; 1,10-Phenanthroline / water / 26 h / 50 °C

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(II) sulfate heptahydrate; potassium carbonate; silver nitrate; In water; acetone;

DOI:10.1002/ejoc.201801601

upstream raw materials:

(1,2-dibromovinyl)benzene

N-[(4-fluorophenyl)methyl]-4-methylbenzenesulfonamide

1-Bromo-2-phenylacetylene

phenylacetylene