(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

Base Information

Chemical Name:(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene
CAS No.:1300614-20-3
Molecular Formula:C₂₃H₃₂O₂SSi
Molecular Weight:400.657
Hs Code.:

Synonyms:(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

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Chemical Property of (Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

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Technology Process of (Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

There total 3 articles about (Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1300614-11-2
(S(S))-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propyne

: 917-54-4
methyllithium

: 1300614-20-3
(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

Guidance literature:: methyllithium; With copper(l) cyanide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

(S(S))-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propyne; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo200373a

Reference yield:

: 1096535-26-0
triethyl((1-phenylprop-2-yn-1-yl)oxy)silane

: 1300614-20-3
(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether / 0 - 20 °C / Inert atmosphere

1.2: -78 - -20 °C / Inert atmosphere

2.1: copper(l) cyanide / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With ethylmagnesium bromide; copper(l) cyanide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo200373a

Reference yield:

: 1517-82-4
(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

: 1300614-20-3
(Z,R(S))-2-methyl-3-phenyl-1-(4-tolylsulfinyl)-3-(triethylsilyloxy)-1-propene

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether / 0 - 20 °C / Inert atmosphere

1.2: -78 - -20 °C / Inert atmosphere

2.1: copper(l) cyanide / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With ethylmagnesium bromide; copper(l) cyanide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo200373a