4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

Base Information

Chemical Name:4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester
CAS No.:117896-45-4
Molecular Formula:C₂₆H₂₇Br₂NO₅
Molecular Weight:593.312
Hs Code.:

Synonyms:4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

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Chemical Property of 4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

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Technology Process of 4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

There total 6 articles about 4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 117896-45-4
4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N

With pyridine; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00122a009

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 117896-45-4
4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N

With pyridine; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00122a009

Reference yield:

: 105189-38-6
(2-methoxyphenyl)(2-methoxypyrid-5-yl)methanol

: 117896-45-4
4-{3,5-Dibromo-4-[4-methoxy-3-(6-methoxy-pyridin-3-ylmethyl)-phenoxy]-phenyl}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 50 °C

2: H₂ / 10percent Pd/C / methanol

3: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

4: Cu bronze, Et₃N

With pyridine; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00122a009