4-Propylthiazol-2-amine

Base Information

• Chemical Name: 4-Propylthiazol-2-amine
• CAS No.: 61764-34-9
• Molecular Formula: C₆H₁₀N₂S
• Molecular Weight: 142.225
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID001313909
• Nikkaji Number: J1.399.401C
• Mol file: 61764-34-9.mol

Synonyms:4-propylthiazol-2-amine;61764-34-9;4-PROPYL-1,3-THIAZOL-2-AMINE;4-Propyl-2-thiazolamine;SCHEMBL5911714;GYKMMCACFINSOH-UHFFFAOYSA-N;4-propyl-1,3-thiazol-2-ylamine;DTXSID001313909;AMY24853;MFCD12406125;AKOS011318878;DS-11252;CS-0187052;FT-0658633;EN300-150015;O11283

Chemical Property of 4-Propylthiazol-2-amine

Chemical Property:

• Vapor Pressure: 0.0159mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 255.9 °C at 760 mmHg
• Flash Point: 108.5 °C
• PSA: 67.15000
• Density: 1.149 g/cm³
• LogP: 2.25900
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 142.05646950
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

4-Propylthiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=CSC(=N1)N

Technology Process of 4-Propylthiazol-2-amine

There total 4 articles about 4-Propylthiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Pentanone (107-87-9) → 2-amino-4-n-propylthiazole (61764-34-9)

Guidance literature:

Reference yield:

ethyl 2-(2-aminothiazol-4-yl)butanoate (412311-88-7) → 2-amino-4-n-propylthiazole (61764-34-9)

Guidance literature:

With sodium hydroxide; anschliessend mit wss. HCl;

DOI:10.1021/ja01856a024

Reference yield:

ethyl 2-ethyl-3-oxobutanoate (607-97-6) → 2-amino-4-n-propylthiazole (61764-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; CS₂ / Behandeln des Reaktionsprodukts mit Thioharnstoff in H₂O

2: ethanolic NaOH / anschliessend mit wss. HCl

With carbon disulfide; sodium hydroxide; bromine;

DOI:10.1021/ja01856a024

upstream raw materials:

ethyl 2-(2-aminothiazol-4-yl)butanoate

ethyl 2-ethyl-3-oxobutanoate

2-Pentanone

Downstream raw materials:

1-Phenethyl-3-(4-propyl-thiazol-2-yl)-thiourea