2,5-Dimethoxy-4-Propylthiophen

Base Information

• Chemical Name: 2,5-Dimethoxy-4-Propylthiophen
• CAS No.: 88441-14-9
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.68
• Hs Code.: 2922299090
• Mol file: 88441-14-9.mol

Synonyms:4-Chloro-2,5-dimethoxyphenethylamine;2C-C;

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Chemical Property of 2,5-Dimethoxy-4-Propylthiophen

Chemical Property:

• Vapor Pressure: 0.000419mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 316.1 °C at 760 mmHg
• PKA: 9.37±0.10(Predicted)
• Flash Point: 144.973 °C
• PSA: 44.48000
• Density: 1.16 g/cm³
• LogP: 2.55870

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dimethoxy-4-Propylthiophen

There total 5 articles about 2,5-Dimethoxy-4-Propylthiophen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

1-(2,5-dimethoxy-4-chlorophenyl)-2-(phthalimidoamino)ethane (88441-16-1) → 1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane (88441-14-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.25h; Heating;

DOI:10.1021/jm00370a014

Reference yield:

C15H22ClNO4 → 1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane (88441-14-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2017.09.024

Reference yield:

2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane (66142-81-2) → 1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane (88441-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / molecular sieves / dimethylformamide / Heating

2: 92 percent / cuprous chloride / dimethylformamide / 5 h / Heating

3: 67.8 percent / 98percent hydrazine / ethanol / 0.25 h / Heating

With molecular sieve; hydrazine hydrate; copper(l) chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00370a014

upstream raw materials:

1-(2,5-dimethoxy-4-chlorophenyl)-2-(phthalimidoamino)ethane

2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane

1-(2,5-dimethoxy-4-bromophenyl)-2-(phthalimidoamino)ethane

3-(2,5-dimethoxyphenyl)propanoic acid

Downstream raw materials:

1-(2,5-dihydroxy-4-chlorophenyl)-2-aminoethane