5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

Base Information

Chemical Name:5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate
CAS No.:446042-83-7
Molecular Formula:C₂₀H₃₃BrF₂O₄SSi
Molecular Weight:515.532
Hs Code.:

Synonyms:5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

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Chemical Property of 5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

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Technology Process of 5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

There total 7 articles about 5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 446042-81-5
5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)methanesulfonate

: 446042-83-7
5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

Guidance literature:: With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0968-0896(02)00062-7

Reference yield:

: 3121-82-2
2,2-dimethylpentane-1,5-diol

: 446042-83-7
5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide

2: 86 percent / triethylamine / tetrahydrofuran / 20 °C

3: 88 percent / N-fluorobenzene-sulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

With 1H-imidazole; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00062-7

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 446042-83-7
5-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2,2-dimethylpentyl (3-bromophenyl)-difluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: Na₂SO₃ / acetone; H₂O / 48 h / Heating

2: 85 percent / phosphorus oxychloride / acetonitrile; tetrahydrothiophene 1,1-dioxide / 3 h / 70 °C

3: 86 percent / triethylamine / tetrahydrofuran / 20 °C

4: 88 percent / N-fluorobenzene-sulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; triethylamine; sodium sulfite; trichlorophosphate; In tetrahydrofuran; sulfolane; water; acetone; acetonitrile;
DOI:10.1016/S0968-0896(02)00062-7