2-BROMO-5-METHOXYBENZONITRILE

Base Information

• Chemical Name: 2-BROMO-5-METHOXYBENZONITRILE
• CAS No.: 138642-47-4
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Hs Code.: 29269090
• Mol file: 138642-47-4.mol

Synonyms:4-Bromo-3-cyanoanisole;4-Bromo-3-cyanoanisole, 6-Bromo-m-anisonitrile;2-BroMo-5-Methoxybenzonitrile 97%

Chemical Property of 2-BROMO-5-METHOXYBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 90-92 °C
• Refractive Index: 1.584
• Boiling Point: 292.774 °C at 760 mmHg
• Flash Point: 130.865 °C
• PSA: 33.02000
• Density: 1.563 g/cm³
• LogP: 2.32938
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-METHOXYBENZONITRILE

There total 13 articles about 2-BROMO-5-METHOXYBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C9H10BrNO2 (1428637-18-6) → 2-bromo-5-methoxybenzonitrile (138642-47-4)

Guidance literature:

With [Ru(η⁶-p-cymene)Cl₂]₂; acrylic acid methyl ester; diphenyl acetylene; In isopropyl alcohol; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41124a

Reference yield: 93.0%

2-bromo-5-methoxy-benzaldehyde oxime (300844-31-9) → 2-bromo-5-methoxybenzonitrile (138642-47-4)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 0 - 20 ℃; for 11h; Inert atmosphere;

DOI:10.1021/ol902902m

Reference yield: 88.0%

2-bromo-5-methoxybenzamide (99848-43-8) → 2-bromo-5-methoxybenzonitrile (138642-47-4)

Guidance literature:

With thionyl chloride; for 3h; Reflux; Inert atmosphere;

DOI:10.1039/c0ob00449a

upstream raw materials:

2-bromo-5-methoxyaniline

2-bromo-5-methoxy-benzaldehyde oxime

4-bromo-3-methylanisole

2-bromo-5-methoxybenzyl bromide

Downstream raw materials:

2-bromo-5-methoxy-benzoic acid

C₈H₈BNO₃

4-(2-cyano-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

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