4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine

Base Information

• Chemical Name: 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine
• CAS No.: 135634-82-1
• Molecular Formula: C₂₃H₃₀N₂O₂
• Molecular Weight: 366.503
• Mol file: 135634-82-1.mol

Synonyms:4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine

Chemical Property of 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine

There total 2 articles about 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-Benzyl-4-<2,2-(ethylenedioxy)-3-(o-nitrophenyl)propyl>piperidine (135634-74-1) → 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine (135634-82-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;

DOI:10.1016/S0040-4020(01)87110-6

Reference yield:

1-(1-benzyl-4-piperydyl)-3-(o-nitrophenyl)-2-propanone (116787-78-1) → 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine (135634-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / p-TsOH*H₂O / benzene / 24 h / Heating

2: 65 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1016/S0040-4020(01)87110-6

Reference yield: 58.0%

benzyl chloride (100-44-7) + 4-<3-(o-Aminophenyl)-2,2-(ethylenedioxy)propyl>-1-benzylpiperidine (135634-82-1) → Benzyl-{2-[2-(1-benzyl-piperidin-4-ylmethyl)-[1,3]dioxolan-2-ylmethyl]-phenyl}-amine (135634-93-4)

Guidance literature:

In ethanol; for 15h; Heating;

DOI:10.1016/S0040-4020(01)87110-6

upstream raw materials:

1-Benzyl-4-<2,2-(ethylenedioxy)-3-(o-nitrophenyl)propyl>piperidine

1-(1-benzyl-4-piperydyl)-3-(o-nitrophenyl)-2-propanone

Downstream raw materials:

Benzyl-{2-[2-(1-benzyl-piperidin-4-ylmethyl)-[1,3]dioxolan-2-ylmethyl]-phenyl}-amine

1-Benzyl-4-(3-phenyl-2-oxopropyl)piperidine

(2RS,5SR,8RS)-2-Benzyl-8-phenyl-2-azabicyclo<3.3.1>nonan-7-one

trans-1-Benzyl-4-(3-phenyl-2-oxopropyl)-2-piperidinecarbonitrile