[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

Base Information

Chemical Name:[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine
CAS No.:1072929-67-9
Molecular Formula:C₂₁H₁₇Cl₂FN₄
Molecular Weight:415.297
Hs Code.:

Synonyms:[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

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Chemical Property of [3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

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Technology Process of [3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

There total 6 articles about [3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 348-54-9
2-Fluoroaniline

: 1072929-68-0
7-chloro-2-(5,6-dichloro-pyridin-3-yl)-1-propyl-1H-benzoimidazole

: 1072929-67-9
[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

Guidance literature:: at 150 ℃; for 3h; Microwave irradiation;

Reference yield:

: 41667-95-2
5,6-dichloronicotinic acid

: 1072929-67-9
[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / toluene / 18 h / 20 - 100 °C

2: tetrahydrofuran / 24 h / 20 - 60 °C

3: 3 h / 150 °C / Microwave irradiation

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 1072928-95-0
(2-chloro-6-nitro-phenyl)-propyl-amine

: 1072929-67-9
[3-chloro-5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(2-fluoro-phenyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / platinum on carbon / tetrahydrofuran / 8 h / 20 °C

2: tetrahydrofuran / 24 h / 20 - 60 °C

3: 3 h / 150 °C / Microwave irradiation

With hydrogen; platinum on carbon; In tetrahydrofuran;