(2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol

Base Information

• Chemical Name: (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol
• CAS No.: 1026486-55-4
• Molecular Formula: C₂₈H₃₇NO₄Si
• Molecular Weight: 479.692

Synonyms:(2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol

Chemical Property of (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol

There total 10 articles about (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2R,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol (193893-12-8) → (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol (1026486-55-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.3987/COM-02-S42

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol (1026486-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / imidazole / CH₂Cl₂ / 20 °C

2: 80 percent / H₂ / Pd/C / ethyl acetate

With 1H-imidazole; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.3987/COM-02-S42

Reference yield:

(2S,3R)-2-azido-4-O-(4-methoxybenzyl)butan-1,3,4-triol (143833-83-4) → (2R,3S)-3-Amino-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol (1026486-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / imidazole / CH₂Cl₂ / 20 °C

2: 80 percent / H₂ / Pd/C / ethyl acetate

With 1H-imidazole; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.3987/COM-02-S42

upstream raw materials:

(2R,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol

(2S,3R)-2-azido-4-O-(4-methoxybenzyl)butan-1,3,4-triol

tert-butylchlorodiphenylsilane

(2R,3S)-2,3-epoxy-4-O-(4-methoxybenzyl)butan-1,4-diol

Downstream raw materials:

Benzoic acid (2S,3S)-3-azido-3-[(1S,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-3-(4-methoxy-benzyloxy)-propylcarbamoyl]-2-methoxymethoxy-propyl ester

(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-5-trifluoromethanesulfonyloxymethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

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