2,5-Dihydro-1H-pyrrole

Base Information

• Chemical Name: 2,5-Dihydro-1H-pyrrole
• CAS No.: 760178-50-5
• Molecular Formula: C₄H₇N
• Molecular Weight: 69.1063
• Hs Code.: 29339900
• Mol file: 760178-50-5.mol

Synonyms:1H-Pyrrole,2,5-dihydro-;;

Chemical Property of 2,5-Dihydro-1H-pyrrole

Chemical Property:

• Vapor Pressure: 54.872mmHg at 25°C
• Refractive Index: 1.461
• Boiling Point: 90.999 °C at 760 mmHg
• PKA: pK1:-0.27(+1) (25°C)
• Flash Point: 5.829 °C
• PSA: 12.03000
• Density: 0.886g/cm³
• LogP: 0.47460
• Storage Temp.: -20°C
• Solubility.: soluble in Alcohol,Chloroform,Ether.
• Water Solubility.: Miscible

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): R11:; R34:
• Hazard Codes: F:Flammable;;
• Statements: R11:; R34:
• Safety Statements: S16:; S26:; S36/37/39:; S45:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dihydro-1H-pyrrole

There total 10 articles about 2,5-Dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-3-pyrroline (73286-70-1) → 3-Pyrroline (109-96-6,760178-50-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1016/j.tet.2003.10.010

Reference yield: 75.0%

<(Z)-4-chloro-2-butenyl>ammonium chloride (7153-66-4) → 3-Pyrroline (109-96-6,760178-50-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; Reflux;

DOI:10.15227/orgsyn.073.0246

Reference yield: 75.0%

2,5-dihydropyrrole-1-carboxylic acid methyl ester (63603-33-8) → 3-Pyrroline (109-96-6,760178-50-5)

Guidance literature:

With methyllithium; lithium bromide; In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

pyrrole

Z-1,4-dichlorobutene

<(Z)-4-chloro-2-butenyl>ammonium chloride

2,5-dihydro-1H-pyrrole hydrochloride

Downstream raw materials:

1-(2,4-dinitro-phenyl)-2,5-dihydro-pyrrole

1-(3-phenylpropanoyl)-2,5-dihydropyrrole

N-{5-[3-fluoro-5-(3-pyrrolin-1-yl)benzamido]-2-methylphenyl}-4-diethylaminomethylbenzamide

1-[(2-nitrobenzene)sulfonyl]-2,5-dihydro-1H-pyrrole

Refernces

• 1、 -. "CRYSTAL AND SALT OF NITROIMIDAZOLE, AND MANUFACTURING METHOD THEREOF". Paragraph 0087-0089. . Retrieved 2019/09/20.
• 2、 Mwangi, Martin T.,Schulz, Michael D.,Bowden, Ned B.. "Sequential reactions with Grubbs catalyst and ad-mix-α//βusing pdms thimbles". supporting information; experimental part. p. 33 - 36. Retrieved 2009/08/08.