(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

Base Information

Chemical Name:(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester
CAS No.:916987-11-6
Molecular Formula:C₃₇H₃₃N₃O₁₀
Molecular Weight:679.683
Hs Code.:

Synonyms:(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

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Chemical Property of (2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

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Technology Process of (2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

There total 3 articles about (2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 916987-09-2
(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester 2-tert-butyl ester

: 916987-11-6
(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo0609125

Reference yield:

: 862177-23-9
(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 916987-11-6
(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / KI; NaHCO₃ / dimethylformamide / 12 h / 20 °C

2: 92 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0609125

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 916987-11-6
(2S,5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,2,5-tricarboxylic acid 1-benzyl ester 5-(p-nitrobenzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / KI; NaHCO₃ / dimethylformamide / 12 h / 20 °C

2: 92 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0609125