ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate

Base Information

• Chemical Name: ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate
• CAS No.: 1257322-93-2
• Molecular Formula: C₁₇H₁₇N₃O₂
• Molecular Weight: 295.341
• Mol file: 1257322-93-2.mol

Synonyms:ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate

Chemical Property of ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate

There total 1 articles about ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

ethyl 6-amino-5-cyano-2-methyl-4-(2-methylphenyl)-4H-pyran-3-carboxylate (72568-51-5) → ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate (1257322-93-2)

Guidance literature:

With ammonium acetate; In acetic acid; for 1.5h; Reflux;

DOI:10.1016/j.tetlet.2010.09.095

Reference yield: 74.0%

ethyl 6-amino-4-(2-methylphenyl)-5-cyano-2-methylnicotinate (1257322-93-2) → (E)-diethyl 6,6'-(diazene-1,2-diyl)bis[4-(2-methylphenyl)-5-cyano-2-methylnicotinate] (1257322-94-3)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In acetonitrile; for 50h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2010.09.095

upstream raw materials:

ethyl 6-amino-5-cyano-2-methyl-4-(2-methylphenyl)-4H-pyran-3-carboxylate

Downstream raw materials:

(E)-diethyl 6,6'-(diazene-1,2-diyl)bis[4-(2-methylphenyl)-5-cyano-2-methylnicotinate]